Faculty Profile

Cynthia Crawford
Ph.D., University of Kentucky, 1992
General Experimental Psychology

Contact Information:


Research and Teaching Interests:

Animal and human models of drug addiction; second messenger system pharmacology; developmental neuropsychopharmacology.

Representative Publications:

McDougall, S.A, Baella, S.A., Stuebner, N.M., Halladay, L.R., Crawford, C.A. Cocaine-induced behavioral sentization in preweanling and adult rats: Effects of a single drug-environment pairing. Psychopharmacology, in press.

Crawford, C.A., Villafranca, S.W., Cyr, M.C., Farley, C.M., Reichel, C.M, Gheorghe, S.L., Krall, C.M., McDougall, S.A (2007). Effects of early methylphenidate exposure on morphine-and sucrose-reinforced behaviors in adult rats: Relationship to dopamine D2 receptors. Brain Research, 1139, 245-253.

Farley, C.M, Baella, S.A., Wacan, J.J, Crawford, C.A., McDogouall, S.A. (2006). Pre- and postsynaptic actions of a partial D2 receptor agonist in reserpinized young rats: Longevity of agonistic effects. Brain Research, 1124, 37-44.

Reichel, C.M., Wacan, J.J., Farley, C.M., Stanley, B.J., Crawford, C.A., McDougall, S.A. (2006). Postnatal manganese exposure attenuates cocaine-induced locomotor activity and reduces dopamine transporters in adult male rats. Neurotoxicology and Teratology, 28, 323-332.

Crawford, C.A, William, M.T., Kohutek, J.L., Choi, F.Y., Yoshida, S. T., McDougall, S.A., Vorhees, C.V. (2006). Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTP?S binding in adult rats, Brain Research, 1077, 178-186.

Yoshida, S.T., Baella, S.A., Stuebner, N.M., Crawford, C.A., McDougall, S.A. (2006). Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats, Brain Research, 1073-1074, 269-275.

Lit, L. Crawford C.A. (2006). Effects of training paradigms on search dog performance. Applied Animal Behaviour Science, 98, 277-292.

McDougall, S, A., Reichel, C.M., Cyr, M.C., Karper, P.E., Nazarian, A., Crawford, C.A. (2005). Importance of D1 receptors for associative components of amphetamine-induced behavioral sensitization and conditioned activity: A study using D1 receptor knockout mice. Psychopharmacology, 183, 20-30.

Armstrong, V., Reichel, C.M., Doti, J.F., Crawford, C.A., McDougall, S.A. (2004). Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen. European Journal of Pharmacology, 488, 111-115.

Crawford, C.A., Choi, F.A., Kohutek, J, Yoshida, S.T., and McDougall, S.A. (2004). Changes in PKA activity and Gsa and Golfa levels after amphetamine- and cocaine-induced behavioral sensitization. Synapse, 51, 241-248.

Crawford, C.A., Willimans, M.T., Newman, E.R., McDougall, S.A., and Vorhees, C.V. (2003). Methamphetamine Exposure During the Preweanling Period Causes Prolonged Changes in Dorsal Striatal Protein Kinase A Activity, Dopamine D2-Like Binding Sites, and Dopamine Content. Synapse, 48, 131-7.

Cepeda, C., Crawford, C.A., Margulies, J.E., Watson, J.B., Levine, M.S., Cohen R.W. (2002). Enhanced Epileptogenic Susceptibility in a Genetic Model of Reactive Synaptogenesis: the Spastic Han-Wistar Rat. Developmental Neuroscience, 24, 262-271.

Karper, P.E., De La Rosa, H., Newman, E.R., Krall, C.M., Nazarian, A., McDougall, S.A., Crawford, C. A. (2002). Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice. Psychopharmacology, 159, 407-414.

Armstrong, V., Nazarian, A., Zavala, A.R., Krall, C.M., Crawford, C.A., McDougall, S.A. (2001). Effects of acute and repeated methamphetamine treatment on the ultrasonic vocalizations of postnatal rats. Pharmacology, Biochemistry and Behavior, 70, 273-278.

McDougall, S. A., Zavala, A. R., Karper, P. E., Abbott, D. L., Figueroa, S. and Crawford, C. A. (2001). Chronic amphetamine exposure during the preweanling period does not affect avoidance learning or novelty-seeking of adults rats. Neurobiology of Learning and Memory, 75, 338-345.

Bandrowski, A. E., Ashe, J. H., Crawford, C. A. (2001). Tetanic stimulation and metabotropic glutamate receptor agonists modify synaptic responses and protein kinase activity in rat auditory cortex. Brain Research, 894, 218-232.

Crawford, C. A., Zavala, A. R., Karper, P. E., and McDougall, S. A. (2000). Long-term effects of postnatal amphetamine treatment on striatal protein kinase A activity, dopamine D1-like and D2-like binding sites, and dopamine content. Neurotoxicology and Teratology, 22, 799-804.

Crawford, C. A., Zavala, A. R., Karper, P. E., Collins, R. L., Loring-Meier, T. E., Watson, J. B., and McDougall, S. A. (2000). Amphetamine treatment during the preweanling period produces enduring changes in striatal protein kinase A activity. Pharmacology, Biochemistry, and Behavior, 66, 835-40.

Zavala, A. R., Nazarian, A., Crawford, C. A., and McDougall, S. A. (2000). Cocaine-induced behavioral sensitization in the young rat. Psychopharmacology, 151, 291-8.

Karper, P. E., Nazarian, A., Crawford, C. A., Drago, J., and McDougall, S. A. (2000). Role of D1 receptors for ?-opioid-mediated locomotor activity and antinociception during the preweanling period: A study using D1 receptor knockout mice. Physiology and Behavior, 68, 585-90.