Faculty Profile

Sanders A. McDougall

Ph.D., University of Kentucky, 1988
General Experimental Psychology

Contact Information:


Research and Teaching Interests:

Recent research in my laboratory has revolved around four topic areas. First, I have a long-term interest in the ontogeny of basal ganglia functioning especially as it relates to unlearned motor movement. Most of this research has focused on interactions between the kappa-opioid and dopamine systems. Second, for the past ten years my laboratory has examined the ontogeny of psychostimulant-induced behavioral sensitization. Initially, my interests focused on the neural substrates (e.g., dopamine and NMDA) underlying sensitization, but more recently we have been examining Pavlovian processes important for behavioral sensitization. Third, in collaboration with Dr. Crawford we have been examining whether various psychostimulants (amphetamine, methamphetamine and MDMA) and heavy metals (manganese) cause long-term behavioral and neural deficits. Fourth, we have been examining both the neuropharmacology and behavioral impact of dopamine partial agonist drugs. Dopamine partial agonists are a class of drugs that are used for the treatment of drug addiction, Parkinson's disease, and various psychiatric conditions.

Courses Taught:

Developmental Psychobiology (PSYC/HD 324)
Drugs and Behavior (PSYC 333)
Biological Psychology (PSYC 363)
Neuropsychiatric Disorders (PSYC 367)
Experimental Psychology: Biological (PSYC 433)
Behavioral Neuroscience (PSYC 442)
Advanced Biological Psychology (PSYC 656)

Honors and Awards:

Professor of the Year Award, CSUSB, 2001

Representative Publications:

Selected Refereed Publications (Student authors are denoted by an asterisk)

*Kozanian OO, *Gutierrez A, *Mohd-Yusof A, McDougall SA (2012) Ontogeny of methamphetamine- and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats. Behavioural Pharmacology 23:367-379

*Der-Ghazarian T, *Gutierrez A, *Varela FA, *Herbert M S, *Amodeo L R, *Charntikov S, Crawford CA, McDougall SA (2012) Dopamine receptor inactivation in the caudate-putamen differentially affects the behavior of preweanling and adult rats. Neuroscience 226:427-440

McDougall SA, *Pothier AG, *Der-Ghazarian T, *Herbert MS, *Kozanian OO, *Castellanos KA *Flores AT (2011) Importance of associative learning processes for the one-trial behavioral sensitization of preweanling rats. Behavioural Pharmacology 22:693–702

McDougall SA,* Kozanian OO, *Greenfield VY, *Horn LR, *Gutierrez A, *Mohd-Yusof A, *Castellanos KA (2011) One-trial behavioral sensitization in preweanling rats: differential effects of cocaine, methamphetamine, methylphenidate, and D-amphetamine. Psychopharmacology 217:559–571

*Charntikov S, *Der-Ghazarian T,* Herbert MS, *Horn LR, *Widarma CB, *Gutierrez A, *Varela FA, McDougall SA (2011) Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats. Neuroscience 183:121–133

McDougall SA, *Der-Ghazarian T, *Britt CE, *Varela FA, Crawford CA (2011) Postnatal manganese exposure alters the expression of D2L and D2S receptor isoforms: relationship to PKA activity and Akt levels. Synapse 65:583–591

*Cortez AM, *Charntikov S, *Der-Ghazarian T, *Horn LR, Crawford CA, McDougall SA (2010) Age-dependent effects of k-opioid receptor stimulation on cocaine-induced stereotyped behaviors and dopamine overflow in the caudate-putamen: an in vivo microdialysis study. Neuroscience 169:203–213

*Herbert MS, *Der-Ghazarian T, *Palmer AG, McDougall SA (2010) One-trial cocaine-induced behavioral sensitization in preweanling rats: role of contextual stimuli. Experimental and Clinical Psychopharmacology 18:284–295

*Der-Ghazarian T, *Charntikov S, *Varela FA, Crawford CA, McDougall SA (2010) Effects of repeated and acute aripiprazole or haloperidol treatment on dopamine synthesis in the dorsal striatum of young rats: comparison to adult rats. Journal of Neural Transmission 117:573–583

McDougall SA, *Cortez AM, *Palmer AG, *Herbert MS, *Martinez CE, *Charntikov S, *Amodeo DA (2009) Importance of environmental context for one- and three-trial cocaine-induced behavioral sensitization in preweanling rats. Psychopharmacology 206:377–388

McDougall SA, *Charntikov S, *Cortez AM, *Amodeo DA, *Martinez CE, Crawford CA (2009) Persistence of one-trial cocaine-induced behavioral sensitization in young rats: Regional differences in Fos immunoreactivity. Psychopharmacology 203:617–628

*Charntikov S, *Halladay LR, *Herbert MS, *Marquez EM, McDougall SA (2008) Effects of dorsal striatal infusions of R(–)-propylnorapomorphine (NPA) on k-opioid-mediated locomotor activity in the young rat: possible role of the indirect pathway. Neuroscience 155:603–612

McDougall SA, *Reichel CM, *Farley CM, *Flesher MM, *Der-Ghazarian T, *Cortez AM, *Wacan JJ, *Martinez CE, *Varela FA, Butt AE, Crawford CA (2008) Postnatal manganese exposure alters dopamine transporter function in adult rats: potential impact on nonassociative and associative processes. Neuroscience 154:848–860

*Iñiguez SD, *Cortez AM, Crawford CA, McDougall SA (2008) Effects of aripiprazole and terguride on dopamine synthesis in the dorsal striatum and medial prefrontal cortex of preweanling rats. Journal of Neural Transmission 115:97–106

McDougall S A, *Baella SA, *Stuebner NM, *Halladay LM, Crawford CA (2007) Cocaine-induced behavioral sensitization in preweanling and adult rats: Effects of a single drug-environment pairing. Psychopharmacology 193:323-332

Crawford CA., *Villafranca SW, *Cyr MC, *Farley CM, *Reichel CM, *Gheorghe SL, *Krall CM, McDougall SA (2007) Effects of early methylphenidate exposure on morphine- and sucrose-reinforced behaviors in adult rats: Relationship to dopamine D2 receptors. Brain Research 1139:245-253

*Farley CM, *Baella SA, *Wacan JJ, Crawford CA, McDougall SA (2006). Pre- and postsynaptic actions of a partial D2 receptor agonist in reserpinized young rats: Longevity of agonistic effects. Brain Research 1124:37-44

*Reichel CM, *Wacan JJ, *Farley CM, Stanley BJ, Crawford CA, McDougall SA (2006) Postnatal manganese exposure attenuates cocaine-induced locomotor activity and reduces dopamine transporters in adult male rats. Neurotoxicology & Teratology 28:323-332

*Yoshida ST, *Baella SA, *Stuebner NM, Crawford CA, McDougall SA (2006) Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats. Brain Research 1073/1074:269-275

Crawford CA, Williams MT, *Kohutek JL, *Choi FY, *Yoshida ST, McDougall SA, Vorhees CV (2006) Neonatal 3,4-methylenedioxymethamphetamine (MDMA) exposure alters neuronal protein kinase A activity, serotonin and dopamine content, and [35S]GTPγS binding in adult rats. Brain Research 1077:178-186

*Wacan JJ, *Reichel CM, *Farley CM, McDougall SA (2006) The partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen. Psychopharmacology 185:104-111

McDougall SA, *Reichel CM, *Cyr MC, *Karper PE, *Nazarian A, Crawford CA (2005) Importance of D1 receptors for associative components of amphetamine-induced behavioral sensitization and conditioned activity: A study using D1 receptor knockout mice. Psychopharmacology 183:20-30

*Krall CM, *Andicochea CT, McDougall SA (2005) Ultrasonic vocalization production of preweanling rats: Effects of central and peripheral administration of α2-adrenoceptor agonists. European Journal of Pharmacology 517:200-207

McDougall SA, *Hernandez RM, *Reichel CM, *Farley CM (2005) The partial D2-like dopamine receptor agonist terguride acts as a functional antagonist in states of high and low dopaminergic tone: Evidence from preweanling rats. Psychopharmacology 178:431-439

*Armstrong V, *Reichel CM, *Doti JF, Crawford CA, McDougall SA (2004) Repeated amphetamine treatment causes a persistent elevation of glial fibrillary acidic protein in the caudate-putamen. European Journal of Pharmacology 488:111-115

Crawford CA, *Choi FY, *Kohutek JL, *Yoshida ST, McDougall SA (2004) Changes in PKA activity and Gsα and Golfα levels after amphetamine- and cocaine-induced behavioral sensitization. Synapse 51:241-248

*Sibole JM, *Matea PJ, *Krall CM, McDougall SA (2003) Effects of a partial dopamine D2-like agonist on the cocaine-induced behavioral sensitization of preweanling rats. Pharmacology, Biochemistry, and Behavior 76:27-34

Crawford CA, Williams MT, *Newman ER, McDougall SA, Vorhees CV (2003) Methamphetamine exposure during the preweanling period causes prolonged changes in dorsal striatal protein kinase A activity, dopamine D2-like binding sites, and dopamine content. Synapse 48:131-137

*Zavala AR, *Yoshida ST, *Osburn JR, McDougall SA (2002) Paradoxical locomotor activating effects of κ-opioid receptor stimulation in the preweanling rat: Role of the ventromedial thalamus and superior colliculus. Developmental Brain Research 139:301-306

*Karper PE, *De La Rosa H, *Newman ER, *Krall CM, *Nazarian A, McDougall SA, Crawford CA (2002) Role of D1-like receptors in amphetamine-induced behavioral sensitization: A study using D1A receptor knockout mice. Psychopharmacology 159:407-414

*Armstrong V, *Nazarian A, *Zavala AR, *Krall CM, Crawford CA, McDougall SA (2001) Effects of acute and repeated methamphetamine treatment on the ultrasonic vocalizations of postnatal rats. Pharmacology, Biochemistry, and Behavior 70:273-278

McDougall SA, *Zavala AR, *Karper PE, *Abbott DL, *Figueroa S, Crawford CA (2001) Chronic amphetamine exposure during the preweanling period does not affect avoidance learning or novelty-seeking of adult rats. Neurobiology of Learning and Memory 75:338-345

*Nazarian A, *Krall CM, *Osburn JR, McDougall SA (2001) Ultrasonic vocalization of preweanling rats: involvement of both α2-adrenoceptor and κ-opioid receptor systems. European Journal of Pharmacology 415:165-171

Crawford CA, *Zavala AR, *Karper PE, McDougall SA (2000) Long-term effects of postnatal amphetamine treatment on striatal protein kinase A activity, dopamine D1-like and D2-like binding sites, and dopamine content. Neurotoxicology and Teratology 22:799-804

Crawford CA, *Zavala A, *Karper PE, *Collins RL, *Meier TL, Watson JB, McDougall SA (2000) Amphetamine treatment during the preweanling period produces long-term changes in striatal protein kinase A activity. Pharmacology, Biochemistry, and Behavior 66:835-840

*Zavala AR, *Nazarian A, Crawford CA, McDougall SA (2000) Cocaine-induced behavioral sensitization in the young rat. Psychopharmacology 151:291-298

*Collins RL, *Zavala AR, *Nazarian A, McDougall SA (2000) κ-Opioid receptors in the substantia nigra pars reticulata mediate the U-50,488-induced locomotor activity of preweanling rats. Developmental Brain Research 119:97-103

*Karper PE, *Nazarian A, Crawford CA, Drago J, McDougall SA (2000) Role of dopamine D1 receptors for κ-opioid mediated locomotor activity and antinociception during the preweanling period: A study using D1 receptor knockout mice. Physiology and Behavior 68:585-590

*Nazarian A, *Rodarte-Freeman AL, McDougall SA (1999) Dopaminergic modulation of kappa opioid mediated ultrasonic vocalizations, antinociception, and locomotor activity in the preweanling rat. Behavioral Neuroscience 113:816-825

McDougall SA, *Collins RL, *Karper PE, Watson JB, Crawford CA (1999) Effects of repeated methylphenidate treatment in the young rat: Sensitization of both locomotor activity and stereotyped sniffing. Experimental and Clinical Psychopharmacology 7:208-218

McDougall SA, *Rodarte-Freeman AL, *Nazarian A (1999) Indirect dopamine agonists augment the locomotor activating effects of the κ-opioid receptor agonist U-50,488 in preweanling rats. Developmental Psychobiology 34:183-193

*Collins RL, *Zavala AR, *Ingersoll VY, Crawford CA, *Duke MA, McDougall SA (1998) Kappa opioid mediated behavioral sensitization in the rat: relationship to Fos immunoreactivity. Psychopharmacology 137:282-291

Crawford CA, McDougall SA, *Meier TL, *Collins RL, Watson JB (1998) Repeated methylphenidate treatment induces behavioral sensitization and decrease protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum. Psychopharmacology 136:34-43

McDougall SA, *Garmsen GM, *Meier TL, Crawford CA (1997) Kappa opioid mediated locomotor activity in the preweanling rat: role of pre and postsynaptic dopamine receptors. Psychopharmacology 133:162-168

*Duke MA, *Meier TL, *Bolanos CA, Crawford CA, McDougall SA (1997) Paradoxical effects of kappa opioid stimulation on the locomotor activity and Fos immunoreactivity of the preweanling rat: role of dopamine receptors. Behavioral Neuroscience 111:1114-1122

*Duke MA, *O'Neal J, McDougall SA (1997) Ontogeny of dopamine agonist-induced sensitization: role of NMDA receptors. Psychopharmacology 129:153-160

*Bolanos CA, *Garmsen GM, *Clair MA, McDougall SA (1996) Effects of the κ-opioid receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat. European Journal of Pharmacology 317:1-8

*Pruitt D, *Bolanos CA, McDougall SA (1995) Effects of dopamine D1 and D2 receptor antagonists on cocaine-induced place preference conditioning in preweanling rats. European Journal of Pharmacology 283:125-131

Crawford CA, McDougall SA, *Bolanos CA, Hall S, Berger SP (1995) The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. Psychopharmacology 120:392-399

McDougall SA, Crawford CA, Nonneman AJ (1995) Age-related differences in dopamine mediated behaviors: Effects of irreversible antagonism. In: NE Spear, LP Spear, ML Woodruff (Eds.), Neurobehavioral plasticity: Learning, development and response to brain insults (pp. 311-333). Hillsdale, NJ: Lawrence Erlbaum Associates.

McDougall SA, *Bolanos CA (1995) The behavioral effects of the reversible dopamine antagonist flupenthixol are not potentiated by EEDQ in the preweanling rat. Pharmacology, Biochemistry and Behavior 50:127-131

Crawford CA, McDougall SA, Bardo MT (1994) Effects of EEDQ on the synthesis and metabolism of dopamine in preweanling and adult rats. Neuropharmacology 33:1559-1565

McDougall SA, *Duke MA, *Bolanos CA, Crawford CA (1994) Ontogeny of behavioral sensitization in the rat: Effects of direct and indirect dopamine agonists. Psychopharmacology 116:483-490

Crawford CA, McDougall SA, Bardo MT (1994) Ontogenetic effects of EEDQ on amphetamine-induced behaviors of rats: Role of presynaptic processes. Psychopharmacology 116:152-160

Crawford CA, *Rowlett JK, McDougall SA, Bardo MT (1994) Age-dependent differences in the rate of recovery of striatal dopamine D1 and D2 receptors after inactivation with EEDQ. European Journal of Pharmacology 252:225-231

McDougall SA, Crawford CA, Nonneman AJ (1993) Behavioral effects of selective and nonselective dopamine agonists on young rats after irreversible antagonism of D1 and/or D2 receptors. Psychopharmacology 111:225-232

*Mestlin M, McDougall SA (1993) Ontogenetic differences in the effects of EEDQ on dopamine mediated behaviors. Pharmacology, Biochemistry and Behavior 45:797-802

McDougall SA, Crawford CA, Nonneman AJ (1992) Effects of dopamine receptor inactivation on the locomotor activity and grooming of young and mature rats. Psychopharmacology 106:502-510

McDougall SA, Crawford CA, Nonneman AJ (1992) Reinforced responding of the 11-day-old rat pup: Synergistic interaction of D-1 and D-2 dopamine receptors. Pharmacology, Biochemistry and Behavior 42:163-168

Crawford CA, McDougall SA, *Rowlett JK, Bardo MT (1992) Depletion of dopamine binding sites and changes in dopamine and dihydroxyphenylacetic acid levels in 17- and 90-day-old rat striatum after irreversible receptor antagonism. Neuroscience Letters 137:265-269

McDougall SA, Bardo MT (1991) Ontogenetic changes in dopaminergic pre and postsynaptic elements in rat brain: Effects of quinpirole and sulpiride. Neuropharmacology 30:531–534

McDougall SA, Nonneman AJ, Crawford CA (1991) Effects of SCH 23390 and sulpiride on the reinforced responding of the young rat. Behavioral Neuroscience 105:744–754

Neisewander JL, McDougall SA, Bowling S, Bardo MT (1990) Aversive and rewarding properties of the nonbenzodiazepine anxiolytics gepirone and buspirone. Psychopharmacology 100:485–490

McDougall SA, Arnold TF, Nonneman AJ (1990) Ontogeny of locomotor activity and grooming in the young rat: Role of D1 and D2 receptors. European Journal of Pharmacology 186:223–230